[Skip to Navigation]
May 1977

Down Syndrome With Trisomy in One Triplet

Author Affiliations

From the Departments of Pediatrics (Dr Kadowaki) and Legal Medicine (Dr Shiono), National Nishi-Sapporo Hospital, and Shakai-Hoken-Chuoo Hospital (Drs Tsuneta, Nagai, and Nanbu), Sapporo, Japan.

Am J Dis Child. 1977;131(5):522-524. doi:10.1001/archpedi.1977.02120180036005

• The case presented here may be the first identified report of Down syndrome with 21 trisomy in one child of triplets. One triplet died at 1 month of age; his facial appearance was not typical of Down syndrome. Detailed testing of blood groups suggested identical origin in the remaining two children. However, the fluorescent banding technique of chromosome, one-way mixed lymphocyte culture test, and HLA typing were suggestive of dizygotic origin. Skin transplant studies supported this contention.

(Am J Dis Child 131:522-524, 1977)

Add or change institution