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May 1977

Urinary Excretion of Phenobarbital in a Neonate Having Withdrawal Symptoms

Author Affiliations

From St Luke's Episcopal Hospital, Houston (Dr Hill) and the Department of Pediatrics (Drs Hill and Verniaud and Ms Morgan) and Institute for Lipid Research (Mss Morgan and Nowlin and Dr Horning), Baylor College of Medicine, Houston.

Am J Dis Child. 1977;131(5):546-550. doi:10.1001/archpedi.1977.02120180060009

• Utilizing methods of gas chromatography-mass spectrometry-computer systems operated in a chemical ionization mode, metabolites of mephobarbital were demonstrated in urines collected from two infants whose mother was treated with mephobarbital during pregnancy. Identification of the major metabolite in one infant was possible for 22 days after delivery. The urinary half-life of mephobarbital was 30 hours and the half-life of phenobarbital was 48 hours. Both infants demonstrated withdrawal symptoms for four to six months and manifested the physical phenotype of infants exposed in utero to anticonvulsant agents.

(Am J Dis Child 131:546-550, 1977)

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