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July 1977

Infections in Patients With Neutropenia

Author Affiliations

From the Departments of Pediatrics and Microbiology and the Comprehensive Cancer Center, University of Alabama in Birmingham (Drs Howard and Johnston), and the Department of Pediatrics, University of Cincinnati College of Medicine, and the Children's Hospital Research Foundation, Cincinnati (Dr Strauss).

Am J Dis Child. 1977;131(7):788-790. doi:10.1001/archpedi.1977.02120200070015

• We review published reports and our experience in regard to the causative organisms of infections in patients with neutropenia. The organisms isolated from infected patients were almost exclusively pyogenic and enteric bacteria, and our patients had no history of serious viral or fungal infections, documenting the importance of the neutrophil in normal host defense against extracellular but not intracellular pathogens. Staphylococcus aureus was the single most commonly cultured organism; however, Pseudomonas and Escherichia coli were almost as commonly isolated. Positive cultures were obtained primarily from the blood or cutaneous, subcutaneous, or deep tissue abscesses. In patients with congenital neutropenia, pneumonia, otitis media, and abscesses were the most frequent infections diagnosed clinically. There is a suggestion that recent antibiotic therapy shifted the spectrum of infecting organisms toward enteric bacteria.

(Am J Dis Child 131:788-790, 1977)

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