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September 1977

Premature Coronary Atherosclerosis in a 5-Year-Old With Corticosteroid-Refractory Nephrotic Syndrome

Author Affiliations

From the Departments of Pediatrics and Pathology, University of Chicago Pritzker School of Medicine, and the Pediatric Nephrology Service, La Rabida Children's Hospital and Research Center, Chicago. Dr Kallen is now with the Cleveland Clinic Foundation, Cleveland; Dr Brynes is with the Department of Pathology, Madison Army Medical Center, Tacoma, Wash; and Dr Lichtig is with the Rambam Government Hospital, Haifa, Israel.

Am J Dis Child. 1977;131(9):976-980. doi:10.1001/archpedi.1977.02120220042006

• We report the case of a 5-year-old girl who died two years after onset of the idiopathic nephrotic syndrome, which failed to respond to treatment with corticosteroid and cyclophosphamide. Severe atherosclerotic changes were noted in both coronary arteries. Prolonged hyperlipidemia in patients with long-standing nephrotic syndrome may represent a major risk factor predisposing to premature coronary atherosclerosis in children who are also destined to develop chronic renal failure.

(Am J Dis Child 131:976-980, 1977)