• A randomized controlled study was undertaken to compare the effectiveness of three umbilical cord treatment regimens in controlling neonatal bacterial colonization. The three regimens studied included castile soap, triple dye, and silver sulfadiazine. The triple dye and silver sulfadiazine application inhibited bacterial colonization. Staphylococcal colonization was inhibited by both treatment regimens but most effectively by triple dye. Group B streptococcal colonization was inhibited most effectively by silver sulfadiazine while triple dye application to the umbilicus promoted colonization with this microorganism. Silver sulfadiazine was more effective in controlling colonization with Gram-negative microorganisms.
(Am J Dis Child 131:1005-1008, 1977)
Speck WT, Driscoll JM, Polin RA, O'Neill J, Rosenkranz HS. Staphylococcal and Streptococcal Colonization of the Newborn Infant: Effect of Antiseptic Cord Care. Am J Dis Child. 1977;131(9):1005–1008. doi:10.1001/archpedi.1977.02120220071012
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