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October 1977

Wheat-Based Diets: Effect of Short-Term Consumption on Serum Cholesterol and Triglyceride Levels in Infants

Author Affiliations

From the Departments of Pediatrics (Drs MacLean and Graham) and International Health (Drs MacLean, Graham, and Lopez de Romaña), the Schools of Medicine and Public Health, Johns Hopkins University, Baltimore, and the Instituto de Investigacion Nutricional, Miraflores (Lima), Peru (Drs MacLean, Graham, and Lopez de Romaña).

Am J Dis Child. 1977;131(10):1119-1121. doi:10.1001/archpedi.1977.02120230065011

• The effect of consumption of wheat-based diets on serum cholesterol and triglyceride levels was studied in eight previously malnourished children. While consuming a control diet of casein, soycottonseed oil blend, and a mixture of sucrose and starch, the serum cholesterol level was 169 ± 42 mg/dl (mean ± SD). This decreased significantly (P <.001) to 108 ± 30 mg/dl after nine days' consumption of an isoenergetic-isonitrogenous diet in which whole wheat or white flour provided all the protein and ± 50% of carbohydrate, and remained at this level for the 27-day dietary period. On changing again to the casein-based diet, the serum cholesterol level rose within nine days to 154 ± 42 mg/dl. There was no similar diet-related change in serum triglyceride values. None of the known mechanisms whereby diet affects serum cholesterol adequately explains these findings.

(Am J Dis Child 131:1119-1121,1977)

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