The features of the Beckwith-Wiedemann syndrome are characterized by exomphalos, macroglossia, macrosomia, visceromegaly, ear lobe anomaly, nevus flammeus, hemihypertrophy, and other abnormalities. Adrenal calcifications can be seen in a variety of pediatric conditions. More than 171 children with the Beckwith-Wiedemann syndrome have been described in the pediatric literature, but none of these patients have been reported as having adrenal calcification.1 The present communication describes two girls with the Beckwith-Wiedemann syndrome who were demonstrated to have adrenal calcifications at ages 7 and 4 years, respectively.
Report of Cases.—Case 1.—This 7-day-old girl was hospitalized because of macrosomia (4.8 kg), macroglossia, and a history of poor feedings. She had been born at term, following a traction delivery. On admission macrosomia, macroglossia, peculiar facies, relative microcephaly, navel hernia, and visceromegaly were striking. Serum bilirubin level on the seventh day of life was 18.8 mg/100 ml. A diagnosis of cretinism was suspected
ICHIBA Y, AOYAMA K. Adrenal Calcification in Beckwith-Wiedemann Syndrome. Am J Dis Child. 1977;131(11):1296–1297. doi:10.1001/archpedi.1977.02120240114025
Coronavirus Resource Center
Customize your JAMA Network experience by selecting one or more topics from the list below.
Create a personal account or sign in to: