[Skip to Content]
[Skip to Content Landing]
December 1977

Incidence of Nelson's Syndrome After Adrenalectomy for Cushing's Disease in Children: Results of a Nationwide Survey

Author Affiliations

From the Children's Hospital of Pittsburgh and the Department of Pediatrics, University of Pittsburgh. Dr Hopwood is currently with the Department of Pediatrics, University of Michigan Medical Center, Ann Arbor.

Am J Dis Child. 1977;131(12):1353-1356. doi:10.1001/archpedi.1977.02120250035005

• To establish the incidence of Nelson's syndrome in children treated with total bilateral adrenalectomy (TBA) for Cushing's disease, a survey was made of members of The Lawson Wilkins Pediatric Endocrine Society. Thirty-one patients aged 10 months to 16 years had been treated with TBA for Cushing's disease; one had been treated with ortho para prime isomer of dichlorodiphenyldichloroethane alone. Postadrenalectomy hyperpigmentation was reported in 18 patients. Sella enlargement was detected in eight patients (25%) after 1 to 5.5 years (mean, three years) post-TBA. Five of these patients have had documented pituitary adenomas to date. This incidence is higher than the adult figure of 10% to 16%.

(Am J Dis Child 131:1353-1356, 1977)