• To establish the incidence of Nelson's syndrome in children treated with total bilateral adrenalectomy (TBA) for Cushing's disease, a survey was made of members of The Lawson Wilkins Pediatric Endocrine Society. Thirty-one patients aged 10 months to 16 years had been treated with TBA for Cushing's disease; one had been treated with ortho para prime isomer of dichlorodiphenyldichloroethane alone. Postadrenalectomy hyperpigmentation was reported in 18 patients. Sella enlargement was detected in eight patients (25%) after 1 to 5.5 years (mean, three years) post-TBA. Five of these patients have had documented pituitary adenomas to date. This incidence is higher than the adult figure of 10% to 16%.
(Am J Dis Child 131:1353-1356, 1977)
Hopwood NJ, Kenny FM. Incidence of Nelson's Syndrome After Adrenalectomy for Cushing's Disease in Children: Results of a Nationwide Survey. Am J Dis Child. 1977;131(12):1353–1356. doi:10.1001/archpedi.1977.02120250035005
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