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February 1978

Retinoblastoma and Subband Deletion of Chromosome 13

Author Affiliations

From the Medical Genetics Division, Department of Laboratory Medicine and Pathology (Dr Yunis) and the Department of Pediatrics (Dr Ramsay), University of Minnesota Medical School, Minneapolis.

Am J Dis Child. 1978;132(2):161-163. doi:10.1001/archpedi.1978.02120270059012

• Two patients with retinoblastoma and an interstitial deletion of the long arm of chromosome 13 were studied using G-banded metaphase and prophase chromosomes. One patient showed several congenital defects, developmental retardation, and deletion of bands q14 and q21. The second patient showed mild developmental delay, a few minor congenital defects, and a loss of approximately half of band q14. On the basis of this study and nine others from the literature, it is now possible to tentatively assign a predisposition to retinoblastoma to deletion of a specific small region of chromosome 13.

(Am J Dis Child 132:161-163, 1978)