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February 1978

Renal Hematuria Associated With Adenovirus 7a Infection

Author Affiliations

Infectious Disease Unit Department of Medicine and Department of Microbiology University of Rochester School of Medicine 601 Elmwood Ave Rochester, NY 14642

Am J Dis Child. 1978;132(2):208-210. doi:10.1001/archpedi.1978.02120270106025

Adenovirus type 7, and the very closely related type 7a, can produce a wide spectrum of illnesses including pharyngitis with accompanying conjunctivitis, cervical adenopathy, and fever.1 Involvement of the urinary tract, however, has not been commonly associated with adenovirus 7, or 7a. We report the case of an 8-year-old boy who had an upper respiratory tract illness accompanied by the appearance of RBCs and RBC casts in the urine. Adenovirus 7a was isolated from the urine, the rectum, and the nasopharynx, and a 16-fold rise in antibody titer to adenovirus was demonstrated.

Report of a Case.—Our patient, an 8-year-old boy with Down's syndrome (documented trisomy of chromosome 21) and atrial-ventricular canal defect entered Strong Memorial Hospital after the rapid onset of fever to 40.6 C. On examination the following abnormalities were noted: petechiae on chest and face, macular rash over lower chest and abdomen, erythema of tympanic membranes,