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March 1978

Nocturnal Intragastric Infusion of Glucose in Management of Defective Gluconeogenesis With Hypoglycemia

Author Affiliations

From the Departments of Pediatrics and Biochemistry, Hospital for Sick Children, Toronto.

Am J Dis Child. 1978;132(3):241-243. doi:10.1001/archpedi.1978.02120280025005

• Three children with defective gluconeogenesis and hypoglycemia were treated with frequent daytime feeding and continuous intragastric infusion of glucose at night. By this technique, the blood glucose level was maintained at or slightly above the physiological range. Secondary lacticacidemia, hyperlipidemia, hyperuricacidemia, and coagulation defects all improved. Weight and height velocity increased dramatically. Strength and sense of well-being improved. Nocturnal intragastric infusion of glucose is now the management of choice for children with defective gluconeogenesis and hypoglycemia.

(Am J Dis Child 132:241-243, 1978)