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March 1978

Toxic Epidermal Necrolysis From Graft-vs-Host DiseaseOccurrence in a Patient With Thymic Hypoplasia

Am J Dis Child. 1978;132(3):282-284. doi:10.1001/archpedi.1978.02120280066013

• An infant with diarrhea, failure to thrive, and a seborrhea-like skin eruption was thought to have fatal familial Leiner's syndrome. Treatment with nonirradiated plasma was followed by graft-vs-host disease and fatal toxic epidermal necrolysis; thymic hypoplasia was found at autopsy. Accurate diagnosis of immunodeficiency syndromes is essential to avoid potentially harmful therapy.

(Am J Dis Child 132:282-284, 1978)