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April 1978

Leukocyte Counts in Children With Sickle Cell Disease: Comparative Values in the Steady State, Vaso-occlusive Crisis, and Bacterial Infection

Author Affiliations

From the Division of Hematology-Oncology, Department of Medicine, Children's Hospital Medical Center, and the Department of Pediatrics, Harvard Medical School, Boston (Drs Buchanan and Glader), and the Department of Pediatrics, University of Texas Health Science Center at Dallas (Dr Buchanan), and the Department of Pediatrics, Stanford University School of Medicine, Stanford, Calif (Dr Glader).

Am J Dis Child. 1978;132(4):396-398. doi:10.1001/archpedi.1978.02120290068013

• Total and differential WBC counts were measured in 88 children with siokle cell hemoglobinopathies during the steady state, vaso-occlusive crisis, and bacterial infection. Steady state leukocyte values were lower than anticipated on the basis of currently available information. Total and segmented leukocyte numbers were greatly increased during vaso-occlusive crisis and infection, but only with bacterial infection was there a consistent increase in bands or nonsegmented leukocytes (mean, 4,580/μl). On the basis of these data we believe that total and differential leukocyte counts are of value for identifying those children with potentially serious bacterial infections.

(Am J Dis Child 132:396-398, 1978)

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