• Total and differential WBC counts were measured in 88 children with siokle cell hemoglobinopathies during the steady state, vaso-occlusive crisis, and bacterial infection. Steady state leukocyte values were lower than anticipated on the basis of currently available information. Total and segmented leukocyte numbers were greatly increased during vaso-occlusive crisis and infection, but only with bacterial infection was there a consistent increase in bands or nonsegmented leukocytes (mean, 4,580/μl). On the basis of these data we believe that total and differential leukocyte counts are of value for identifying those children with potentially serious bacterial infections.
(Am J Dis Child 132:396-398, 1978)
George R. Buchanan, Bertil E. Glader. Leukocyte Counts in Children With Sickle Cell DiseaseComparative Values in the Steady State, Vaso-occlusive Crisis, and Bacterial Infection. Am J Dis Child. 1978;132(4):396–398. doi:10.1001/archpedi.1978.02120290068013