• Racemic epinephrine has been advocated for the treatment of croup, but controlled studies have not proved it more effective than saline. Twenty patients (aged 4 months to 5 years) hospitalized with acute croup and persistent inspiratory stridor at rest were randomly assigned to one of two treatment groups: saline or racemic epinephrine, both nebulized and delivered by intermittent positive pressure breathing. Clinical scores were significantly improved (P <.01) at ten and 30 minutes following the treatment with racemic epinephrine but not at 120 minutes. Racemic epinephrine was significantly more effective than saline at 10 (P <.01) and 30 minutes (P <.05) but not at 120 minutes after the treatment. We conclude that nebulized racemic epinephrine is effective treatment for the acute signs of croup.
(Am J Dis Child 132:484-487, 1978)
Westley CR, Cotton EK, Brooks JG. Nebulized Racemic Epinephrine by IPPB for the Treatment of CroupA Double-Blind Study. Am J Dis Child. 1978;132(5):484–487. doi:10.1001/archpedi.1978.02120300044008