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June 1978

Neonatal Coccidioidomycosis in Premature Twins

Author Affiliations

Riverside General Hospital University Medical Center 9851 Magnolia Ave Riverside, CA 92503

Am J Dis Child. 1978;132(6):634. doi:10.1001/archpedi.1978.02120310098021

Several cases of neonatal coccidioidomycosis have been reported.1-3 All but one infant appeared to have acquired the infection postnatally with no associated maternal infection.4 We now report the occurrence of coccidioidomycosis in premature twins with maternal disseminated infection.

Report of Cases.—Maternal History.—A 35-year-old black woman was admitted to the hospital in spontaneous premature labor. She had been in apparent good health until two weeks earlier when she had developed a cough and fever. Her symptoms had progressed until the day of admission, when she developed high fever, tachypnea, and cyanosis. She gave birth to two preterm twins within one-half hour following admission to the hospital, following which her condition deteriorated and she died 24 hours later. Postmortem examination disclosed disseminated coccidioidomycosis, involving many organs, but sparing the uterus and placenta.

Twin A.-This preterm female infant weighing 850 g was transferred to the intensive care nursery at Riverside