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June 1978

Spinal Fluid LDH Activity in Children With Acute Leukemia

Author Affiliations

Department of Pediatrics David Grant USAF Medical Center Travis AFB, CA 94535; Oncology-Hematology Department and Pathology Department The Children's Hospital University of Colorado Medical Center Denver, CO 80262

Am J Dis Child. 1978;132(6):634-635. doi:10.1001/archpedi.1978.02120310098022

Early diagnosis of central nervous system leukemia may be difficult. Aseptic meningitis and CNS leukemia may produce similar clinical findings in leukemic children, and routine spinal fluid studies may not always accurately differentiate these.1-3 Cerebrospinal fluid lactic dehydrogenase (LDH) activity is usually normal in aseptic meningitis4 and high in adults with CNS leukemia.5 In an attempt to determine the diagnostic usefulness of measuring CSF LDH activity in leukemic children, the present report summarizes the results of sequential measurements of CSF LDH activity in a large number of children with acute lymphoblastic leukemia with and without CNS relapse.

Subjects and Methods.—Sequential spinal fluid examinations including blood cell counts, differential cell counts, cytology studies, and measurements of LDH activity were performed in 41 children with acute lymphoblastic leukemia, using standard laboratory methods.2,6,7 All incomplete examinations or bloody specimens were excluded from the study. None of the patients