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August 1978

Erythroid Hypoplasia: An Unusual Presentation of Childhood Acute Lymphocytic Leukemia

Author Affiliations

From the Department of Pediatrics, State University of New York, Upstate Medical Center, Syracuse.

Am J Dis Child. 1978;132(8):763-764. doi:10.1001/archpedi.1978.02120330035008

• A 3-year-old girl had pancytopenia and bone marrow erythroid hypoplasia. The pancytopenia resolved without therapy, but the erythroid hypoplasia persisted for four months in spite of a five-week course of corticosteroid therapy. She responded briefly when androgens were added to the corticosteroid regimen, but within three weeks of stopping therapy she developed acute lymphocytic leukemia. The differential diagnosis of RBC aplasia in childhood is discussed. To our knowledge, this is the first case reported with erythroid hypoplasia as a prodrome of acute lymphocytic leukemia of childhood.

(Am J Dis Child 132:763-764, 1978)

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