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January 1979

Gold Nephropathy in Juvenile Rheumatoid Arthritis

Author Affiliations

From the Department of Internal Medicine, Section of Nephrology (Dr Husserl), and the Departments of Pediatrics and Nuclear Medicine (Dr Shuler), Ochsner Medical Institutions, New Orleans.

Am J Dis Child. 1979;133(1):50-52. doi:10.1001/archpedi.1979.02130010056010

• A 2-year-old girl was treated with gold salts for juvenile rheumatoid arthritis. Treatment had to be discontinued when persistent proteinuria was detected. As this case report indicates, close monitoring of the urine is mandatory during treatment with gold salts to detect early signs of toxicity: hematuria followed by casts and then proteinuria as therapy is continued. Histologic examination with electron microscopy will help to differentiate the different forms of gold toxicity. When the findings are consistent with gold-induced renal involvement, therapy should be discontinued. The gold nephropathy usually resolves in time, with no permanent renal damage.

(Am J Dis Child 133:50-52, 1979)

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