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February 1979

Familial Pyloric Atresia

Author Affiliations

Department of Pediatrics Southern California Permanente Medical Group 1050 W Pacific Coast Hwy Harbor City, CA 90710

Am J Dis Child. 1979;133(2):221. doi:10.1001/archpedi.1979.02130020113026

Sir.—Konvolinka and Steward (Am J Dis Child 132:903-905, 1978) describe a patient with pyloric atresia and report 81 cases in the medical literature. Although they do not discuss the possible recurrence in siblings, Tan and Murugasu1 (authors' reference 24) considered their report of affected siblings the first in the literature. Actually, there are at least five other families,2 leading the authors of one article3 to suggest the condition is inherited in an autosomal recessive manner. Presumably, α-fetoprotein levels would be elevated in the amniotic fluid of succeeding affected siblings, which suggests the possibility of prenatal diagnosis.4

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