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March 1979

Systemic Group D Streptococcal Infection in Newborn Infants

Author Affiliations

From the Divisions of Newborn (Drs Ciambarella and Light) and Pathology (Dr Buchino), of the Department of Pediatrics at the University of Cincinnati College of Medicine, at the Children's Hospital Medical Center, and at the Children's Hospital Research Foundation, Cincinnati.

Am J Dis Child. 1979;133(3):270-273. doi:10.1001/archpedi.1979.02130030046007

• Thirteen cases of group D streptococcal neonatal sepsis and/or meningitis were identified at the Cincinnati Children's Hospital from 1970 to 1976. Ages at onset of disease ranged from 1 to 25 days. The most frequent symptoms were fever (five cases), lethargy (five cases), and respiratory difficulty (four cases). Blood cultures for seven infants were positive; CSF cultures for five infants were positive; and CSF and blood cultures for one infant were both positive. In 12 patients, parenteral antibiotic therapy consisted of a penicillin and an aminoglycoside. One infant with a severe meningomyelocele died. The other 12 infants showed a rapid clinical response with seven patients improving within 48 hours of the start of therapy. Infection with group D streptococcus results in a low-grade systemic disease in both full-term and premature infants that responds favorably to appropriate therapy.

(Am J Dis Child 133:270-273, 1979)

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