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March 1979

Y-Autosome Translocation, Gonadal Dysgenesis, and Gonadoblastoma

Author Affiliations

From the Department of Obstetrics and Gynecology, University of Texas Health Science Center at San Antonio. Dr Ong is in private practice in Beeville, Tex.

Am J Dis Child. 1979;133(3):277-282. doi:10.1001/archpedi.1979.02130030053009

• A 5-year-old girl was discovered to have an abnormal karyotype with a translocation involving the Y chromosome. The primary complaint was slight physical growth retardation. Cytogenetic and endocrinologic evaluations were performed. The chromosomal complement exhibited a mosaicism: 45,X,t(Y;18)(q11;p11)/45,X0. The gonads of this patient were typical streaks containing no ova or follicles. A gonadoblastoma was present bilaterally.

(Am J Dis Child 133:277-282, 1979)

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