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March 1979

Studies of 16-Androstenes in an Infant With Virilizing Adrenal Carcinoma

Author Affiliations

From the Department of Pediatrics, State University of New York, Upstate Medical Center, Syracuse, NY (Ms Gregory and Drs Gardner and Barlow), and the Department of Biochemistry and Chemistry, Guy's Hospital Medical School, London (Dr Gower and Mr Bicknell). Dr Barlow is now at the US Army Health Clinic, Fort Monroe, Va, and Mr Bicknell is now at the Imperial Cancer Research Fund, London.

Am J Dis Child. 1979;133(3):294-297. doi:10.1001/archpedi.1979.02130030070012

• An 18-month-old girl with virilization was found to have an encapsulated right adrenal carcinoma (2 × 3 cm) with great variation in nuclear size, frequent mitoses, and possible blood vessel invasion. Preoperative urinary excretions of 17-ketosteroids, androsterone, etiocholanolone, dehydroepiandrosterone, testosterone, pregnanetriol, 3α-androstenol, and 3β-androstadienol were elevated; all showed a noticeable decrease postoperatively. Cortisol acetate, given preoperatively, produced a definite decrease in the urinary excretion of 17-ketosteroids and dehydroepiandrosterone; administration of corticotropin resulted in an increase in levels of urinary 17-ketosteroids, 17-hydroxycorticosteroids, and pregnanetriol. Urinary testosterone and 3β-androstadienol may have diagnostic value since neither was suppressed by cortisol therapy. The behavior of both 3α-androstenol and 3β-androstadienol in this study suggests that they are of adrenal origin.

(Am J Dis Child 133:294-297, 1979)

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