• The frequency of germ cell neoplasms in girls with 46-XY gonadal dysgenesis suggests that germ cells may persist in the dysgenetic gonads for many years. A phenotypic female infant with a karyotype of 46-XY in blood, skin, and gonads had a few ova in primordial follicles and numerous germ cells in her dysgenetic gonads at the age of 3 months. At 3 years and 10 months of age her gonads contained no primordial follicle and the only remaining germ cells were in a gonadoblastoma. We propose that germ cells are lost from dysgenetic gonads much more rapidly than from normal gonads, but that the rate of loss in patients with a karyotype of 46-XY may be less than the rate of loss in patients with a karyotype of 45-XO.
(Am J Dis Child 133:373-375, 1979)
Cussen LJ, MacMahon RA. Germ Cells and Ova in Dysgenetic Gonads of a 46-XY Female Dizygotic Twin. Am J Dis Child. 1979;133(4):373–375. doi:10.1001/archpedi.1979.02130040027005
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