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April 1979

Germ Cells and Ova in Dysgenetic Gonads of a 46-XY Female Dizygotic Twin

Author Affiliations

From the Department of Pediatrics, Monash University (Dr Cussen and Dr MacMahon), and the Department of Pathology, Queen Victoria Medical Centre (Dr Cussen), Melbourne, Australia.

Am J Dis Child. 1979;133(4):373-375. doi:10.1001/archpedi.1979.02130040027005

• The frequency of germ cell neoplasms in girls with 46-XY gonadal dysgenesis suggests that germ cells may persist in the dysgenetic gonads for many years. A phenotypic female infant with a karyotype of 46-XY in blood, skin, and gonads had a few ova in primordial follicles and numerous germ cells in her dysgenetic gonads at the age of 3 months. At 3 years and 10 months of age her gonads contained no primordial follicle and the only remaining germ cells were in a gonadoblastoma. We propose that germ cells are lost from dysgenetic gonads much more rapidly than from normal gonads, but that the rate of loss in patients with a karyotype of 46-XY may be less than the rate of loss in patients with a karyotype of 45-XO.

(Am J Dis Child 133:373-375, 1979)

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