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May 1979

Hepatoma in a Child With Neurofibromatosis

Author Affiliations

From the Department of Pediatrics, Roswell Park Memorial Institute, Buffalo. Dr Ettinger is now with the Department of Pediatrics, University of Rochester Medical Center, Strong Memorial Hospital, Rochester, NY.

Am J Dis Child. 1979;133(5):528-531. doi:10.1001/archpedi.1979.02130050072015

• A 6-year-old girl had neurofibromatosis and hepatocellular carcinoma (hepatoma). Although neurofibromatosis is a common disorder, hepatic cancers are rare in childhood. Hepatic cancer, Wilms' tumor, and adrenocortical neoplasia are all seen with increased frequency in association with certain congenital anomalies, particularly with hemihypertrophy and various hamartomas. Neurofibromatosis, a hamartomatous disorder, is also seen with these congenital anomalies and it is reported with an unusually high incidence in patients with Wilms' tumor. We therefore suggest that these disorders may be related.

(Am J Dis Child 133:528-531, 1979)

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