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June 1979

Phototherapy and Plasma Immunoreactive Prostaglandin A Values: Its Effect in Premature Infants

Author Affiliations

From the Divisions of Perinatal Medicine (Drs Aplin and Richardson) and Nephrology (Drs Brouhard, Cunningham, and Richardson), University of Texas Medical Branch, Galveston.

Am J Dis Child. 1979;133(6):625-627. doi:10.1001/archpedi.1979.02130060065014

• Plasma immunoreactive prostaglandin A (iPGA) values were determined for 14 premature infants before and after 48 hours of phototherapy and in a control group of six age-matched premature infants. At 4 to 8 days of life, the infants who had received phototherapy for 48 hours had significantly lower iPGA values compared with controls. At 2 to 3 days of life, four infants with a clinically apparent patent ductus arteriosus were found to have significantly elevated iPGA values compared with controls. After 48 hours of phototherapy, these infants likewise had a significant decrease in iPGA values compared with controls; in all four infants, the ductus closed spontaneously. Phototherapy is an effective method for decreasing plasma iPGA values in premature infants.

(Am J Dis Child 133:625-627, 1979)

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