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October 1979

Acute Renal Failure in Reye's Syndrome

Author Affiliations

From the Departments of Pediatrics (Drs Baliga, Fleischmann, Sarnaik, and Bidani) and Pathology (Dr Chang) and the Reye Syndrome Study Center (Dr Arcinue), Children's Hospital of Michigan, Detroit; and Wayne State University School of Medicine (Drs Baliga, Fleischmann, Sarnaik, Bidani, and Chang), Detroit.

Am J Dis Child. 1979;133(10):1009-1013. doi:10.1001/archpedi.1979.02130100033006

• Three patients with initial clinical manifestations and biochemical findings suggestive of a diagnosis of Reye's syndrome had acute renal insufficiency develop and had evidence of consumptive coagulopathy, not generally considered features of the syndrome. As a group, they could not be distinguished, either on the basis of their clinical manifestations or liver pathologic findings, from the 17 patients with Reye's syndrome without renal failure seen in our institution during the same period of time. The use of osmotic diuretics in an effort to decrease cerebral edema may be life threatening in these patients with compromised renal function since hypervolemia, cardiac failure, and worsening of cerebral edema may occur.

(Am J Dis Child 133:1009-1013, 1979)

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