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November 1979

Rubella Vaccination-Reply

Author Affiliations

The Hospital for Sick Children Great Ormond St London WC1

Am J Dis Child. 1979;133(11):1203. doi:10.1001/archpedi.1979.02130110110028

In Reply.—I agree with Preblud and his colleagues that the most effective way of evaluating the immune status of the girls who seem to be seronegative is by revaccination and subsequent serological retest. This should not be too difficult in practice. I regret that1 I did not refer to the valuable studies of Weibel et al2 and others3 on the persistence of antibody after vaccination. These are distinctly encouraging, but nevertheless, in my opinion, long-term surveillance along the lines carried out by Krugman4 in respect of measles vaccine is necessary to determine the duration of immunity after early childhood immunization with rubella vaccines.