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December 1979

Further Evaluation of the Optimum Age for Rubella Vaccine Administration

Author Affiliations

From the Department of Pediatrics and the Hastings Foundation Infectious Disease Research Laboratory of the University of Southern California School of Medicine, Los Angeles; and the Department of Pediatrics, Los Angeles County-University of Southern California Medical Center, Los Angeles.

Am J Dis Child. 1979;133(12):1237-1239. doi:10.1001/archpedi.1979.02130120029004

• The hemagglutination-inhibition (HI) antibody responses of 452 children to HPV-77,DE5 rubella vaccine were studied. Results indicated that seroconversion rates and geometric mean titers in infants inoculated at 12 through 14 months of age are comparable with those achieved in older children. "Vaccine failures" seem to occur randomly in vaccinees after 1 year of age; the infectivity of individual vaccines is questioned. The persistence of HI antibody was evaluated through serial sampling up to three years postinoculation.

(Am J Dis Child 133:1237-1239, 1979)

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