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December 1979

Transfer of Measles, Mumps, and Rubella Antibodies From Mother to Infant: Its Effect on Measles, Mumps, and Rubella Immunization

Author Affiliations

From the Division of Virology, Bureau of Biologics, Food and Drug Administration, Public Health Service, Department of Health, Education, and Welfare, (Drs Sato, Albrecht, and Ennis); and the Department of Pediatrics, University of Alabama in Birmingham (Drs Reynolds and Stagno). Dr Sato is now with the Department of Measles Virus, National Institute of Health of Japan, Tokyo.

Am J Dis Child. 1979;133(12):1240-1243. doi:10.1001/archpedi.1979.02130120032005

• Sera from 42 mother-infant pairs were examined to determine the effect of passively acquired enhanced neutralizing (ENt) antibody on immunization. The ENt antibodies to measles, mumps, and rubella were greater in term newborns than in their mothers, with a mean ratio of 1.8:1, 1.3:1, and 1.2:1, respectively. In 21% to 25% of the children, these antibodies persisted until 12 months of age. When immunized with trivalent measlesmumps-rubella vaccine, children who had persisting ENt measles and rubella titers had significantly lower mean antibody responses than children without detectable antibodies to the two viruses. Persisting ENt mumps antibodies did not affect the postimmunization titers. Seroconversion rates to any of the three viruses were not different in children with or without preexisting ENt antibody.

(Am J Dis Child 133:1240-1243, 1979)

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