Cystic fibrosis (CF), an inherited, chronic progressive disease, is considered a cause of failure to thrive and retarded growth. In fact, special growth curves have been constructed for patients with CF.1,2 However, most patients with CF who survive to adulthood achieve stature in the normal range.3 Thus, when severe growth retardation is observed in a patient with CF, it should not be attributed to CF alone and other etiologies should be sought. We have described two patients with CF who have isolated human growth hormone (HGH) deficiency.
Report of Cases.—Case 1.—A 14-year, 8-month-old boy was found to have elevated sweat sodium and chloride concentrations at age 2 years, 9 months during an evaluation for short stature. However, at that time, he had no demonstrable respiratory or gastrointestinal disease, and other than his size and a submucosal cleft palate, physical examination showed no abnormalities. By age 5
HUBBARD VS, DAVIS PB, DI SANT'AGNESE PA, GORDEN P, SCHWARTZ RH. Isolated Growth Hormone Deficiency and Cystic Fibrosis: A Report of Two Cases. Am J Dis Child. 1980;134(3):317–319. doi:10.1001/archpedi.1980.02130150071018
Customize your JAMA Network experience by selecting one or more topics from the list below.
Create a personal account or sign in to: