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June 1980

Encephalopathy in Young Children With Moderate Chronic Renal Failure

Author Affiliations

From the Divisions of Pediatric Neurology (Drs Bale and Bray) and Nephrology (Dr Siegler), Departments of Neurology and Pediatrics, University of Utah College of Medicine, Salt Lake City.

Am J Dis Child. 1980;134(6):581-583. doi:10.1001/archpedi.1980.02130180039012

• We studied three boys who had a similar encephalopathy develop during moderate chronic renal failure. The features included cerebellar system dysfunction, seizures, and intellectual and motor retardation. Extensive laboratory investigation failed to disclose an etiology other than chronic azotemia. These cases suggest that the developing nervous system is particularly sensitive to the effects of chronic azotemia. Early dialysis and/or transplantation should be considered in such children in an attempt to modify the serious nervous system abnormalities.

(Am J Dis Child 134:581-583, 1980)

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