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June 1980

Intravenous Aminophylline Therapy for Asthma: A Comparison of Two Methods of Administration in Children

Author Affiliations

From the Department of Pediatrics, National Jewish Hospital, Denver (Drs Goldberg and Leffert); the Department of Biometrics, University of Colorado Medical Center, Denver (Dr Zerbe); and the University of Colorado School of Pharmacy, Boulder (Dr Gonzalez and Mr Gogenola). Dr Goldberg is now in private practice in Bridgeport, Conn; Dr Leffert is now with the Department of Pediatrics, University of Chicago, Pritzker School of Medicine; and Dr Gonzalez is now with the School of Pharmacy, Purdue University, West Lafayette, Ind.

Am J Dis Child. 1980;134(6):596-599. doi:10.1001/archpedi.1980.02130180054016

• Eleven asthmatic children were given intravenous aminophylline by two methods of administration: a 6 mg/kg loading dose followed by a 1.1 mg/kg/hr continuous infusion, or a bolus of 4 mg/kg given every four hours. Expiratory flow rates (forced expiratory volume at 1 s and expiratory flow at 50% of vital capacity) were recorded at intervals for 24 hours with each regimen. Although the intermittent administration of aminophylline produced a substantial improvement, there was a significantly greater pulmonary response to continuous infusion.

(Am J Dis Child 134:596-599, 1980)