• Eleven asthmatic children were given intravenous aminophylline by two methods of administration: a 6 mg/kg loading dose followed by a 1.1 mg/kg/hr continuous infusion, or a bolus of 4 mg/kg given every four hours. Expiratory flow rates (forced expiratory volume at 1 s and expiratory flow at 50% of vital capacity) were recorded at intervals for 24 hours with each regimen. Although the intermittent administration of aminophylline produced a substantial improvement, there was a significantly greater pulmonary response to continuous infusion.
(Am J Dis Child 134:596-599, 1980)
Goldberg P, Leffert F, Gonzalez M, Gogenola L, Zerbe GO. Intravenous Aminophylline Therapy for Asthma: A Comparison of Two Methods of Administration in Children. Am J Dis Child. 1980;134(6):596–599. doi:https://doi.org/10.1001/archpedi.1980.02130180054016
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