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June 1980

Cholelithiasis Associated With the Hemolytic-Uremic Syndrome

Author Affiliations

Department of Pediatrics; Department of Radiology; Department of Surgery Children's Hospital of Michigan and Wayne State University School of Medicine Detroit, MI 48201

Am J Dis Child. 1980;134(6):622. doi:10.1001/archpedi.1980.02130180078023

The hemolytic-uremic syndrome (HUS) exhibits a prodrome characterized by prominent gastrointestinal (GI) symptoms including vomiting, diarrhea that is often bloody, and colicky abdominal pain.1-3 Persistent vomiting and abdominal pain continued after return of normal renal function and cessation of hemolysis in a 15-year-old girl with severe HUS. She was found to have cholecystitis because of calcium bilirubinate stones, which developed as a consequence of hemolysis. Cholelithiasis occurring as a complication of HUS has not previously been reported.

Report of a Case.—A previously healthy 15-year-old girl had anuria after five days of vomiting and bloody diarrhea. The diagnosis of HUS was made because of renal failure, anemia, thrombocytopenia, and the presence of many schistocytes on peripheral smear. The patient was then transferred to the Children's Hospital of Michigan, Detroit, where she remained anuric for 11 days. She required eight hemodialysis treatments and four transfusions of packed RBCs. Platelet counts

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