• Five patients with juvenile chronic granulocytic leukemia are described. Two patients had multiple cafe-au-lait spots compatible with von Recklinghausen's neurofibromatosis, and three had cutaneous xanthomata. Recurrent cutaneous leukemic infiltrates were noted in two patients. The clinical course of all five patients was characterized by recurrent respiratory symptoms and pulmonary infiltrates that responded to antileukemic therapy in three. Chemotherapy controlled the symptoms but did not influence the eventually fatal outcome.
(Am J Dis Child 134:654-658, 1980)
Mays JA, Neerhout RC, Bagby GC, Koler RD. Juvenile Chronic Granulocytic Leukemia: Emphasis on Cutaneous Manifestations and Underlying Neurofibromatosis. Am J Dis Child. 1980;134(7):654–658. doi:10.1001/archpedi.1980.02130190022006
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