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July 1980

Juvenile Chronic Granulocytic Leukemia: Emphasis on Cutaneous Manifestations and Underlying Neurofibromatosis

Author Affiliations

From the Departments of Pediatrics (Drs Mays and Neerhout) and Medicine (Drs Bagby and Koler), University of Oregon School of Medicine and the Doernbecher Memorial Hospital for Children, Portland.

Am J Dis Child. 1980;134(7):654-658. doi:10.1001/archpedi.1980.02130190022006

• Five patients with juvenile chronic granulocytic leukemia are described. Two patients had multiple cafe-au-lait spots compatible with von Recklinghausen's neurofibromatosis, and three had cutaneous xanthomata. Recurrent cutaneous leukemic infiltrates were noted in two patients. The clinical course of all five patients was characterized by recurrent respiratory symptoms and pulmonary infiltrates that responded to antileukemic therapy in three. Chemotherapy controlled the symptoms but did not influence the eventually fatal outcome.

(Am J Dis Child 134:654-658, 1980)

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