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September 1980

Mitogenic Response to Toxocara Antigen and Chemotactic Defect in Visceral Larva Migrans

Author Affiliations

From the Departments of Medicine (Drs Caldwell and Lobell) and Pediatrics (Dr Coccia), University of Minnesota Medical School, Minneapolis; and the United Hospitals (Drs Caldwell and Lobell), St Paul.

Am J Dis Child. 1980;134(9):845-847. doi:10.1001/archpedi.1980.02130210029008

• A 3-year-old girl had the typical features of visceral larva migrans syndrome, including hypereosinophilia, recurrent pulmonary infiltrates, and elevated serum IgG, IgE, and isohemagglutinin titers. A marked mitogenic response of her cultured lymphocytes to Toxocara antigen but not to Ascaris antigen was found. A neutrophil chemotactic abnormality to Escherichia coli culture filtrates and zymosan-activated sera was also demonstrated, which partially corrected after she was treated with diethylcarbamazine citrate.

(Am J Dis Child 134:845-847, 1980)

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