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Article
October 1980

Congenital Leukemoid Reaction Followed by Fatal Leukemia: A Case With Down's Syndrome

Author Affiliations

From the Departments of Pediatrics (Dr Lin) and Pathology (Drs Menaka and Lim), Faculty of Medicine and the Department of Genetics (Dr Yong), Faculty of Science, University of Malaya, Kuala Lumpur, Malaysia.

Am J Dis Child. 1980;134(10):939-941. doi:10.1001/archpedi.1980.02130220017005
Abstract

• A serial clinical, hematologic, and cytogenetic study was done on a baby with Down's syndrome in whom a myeloid leukemoid reaction developed at birth that spontaneously regressed within a month only to relapse two years later to an acute undifferentiated stem cell leukemia. He died 1½ months after onset. The unresolved controversy of the diagnosis of the congenital leukemia-like state is discussed. The importance of following up such patients with apparent remission of their congenital leukemia-like disorder is emphasized.

(Am J Dis Child 134:939-941, 1980)

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