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The application of recently developed technology to the study of hemoglobin synthesis has led to a sudden expansion of the literature that deals with the hemoglobinopathies and thalassemia. Complete chromosome mapping of the globin genetic regions has been accomplished with bacterial restriction endonucleases, and sequence analysis of DNA and RNA has been facilitated with "probes" of complementary DNA and recombinant technology. As a result, the genetic and molecular flaws underlying disorders of hemoglobin synthesis can be defined with far greater precision than has heretofore been possible. Hemoglobinopathies in Children, the third volume in the Progress in Pediatric Hematology and Oncology series, is welcomed as a timely synthesis of this newly acquired knowledge. It is authored by 27 persons active in the field and edited by Elias Schwartz, whose clinical and laboratory contributions to the subject are substantial.
The 16 chapters of the treatise are grouped into three sections: normal and