[Skip to Content]
[Skip to Content Landing]
January 1981

Treatment of Early-Onset Neonatal Hypocalcemia: Effects on Serum Calcium and Ionized Calcium

Author Affiliations

From the Division of Neonatology, Department of Pediatrics (Dr Brown and Ms Steranka) and the Department of Community Medicine (Dr Taylor), University of Pittsburgh School of Medicine.

Am J Dis Child. 1981;135(1):24-28. doi:10.1001/archpedi.1981.02130250012006

• For the treatment of early-onset neonatal hypocalcemia, 50 neonates received either a high dose (group H), a low dose (group L), or no parenteral calcium (Ca) (group CON). Groups H and L received parenteral Ca either as a continuous infusion (group C) or by intermittent injection (group I). After the first 24 hours of treatment, groups H, C, and I had higher serum Ca concentrations than did group CON. After the entire 72-hour study period, group H had a lower incidence of hypocalcemia (serum Ca level < 7.0 mg/dL) when compared with all other patients. Although a relatively high Ca intake statistically increased serum Ca levels, eight of 13 patients in group CON (62%) completed the 72-hour study without requiring parenteral Ca. Based on these results, we recommend parenteral Ca treatment for only those patients with persistent hypocalcemia, tetany, or a seizure disorder.

(Am J Dis Child 135:24-28, 1981)