[Skip to Navigation]
February 1981

Hyperthyroidism in Children: A Reevaluation of Treatment

Author Affiliations

From the Division of Endocrinology and Metabolism, Department of Pediatrics (Drs Buckingham, Costin, Roe, and Kogut), and the Division of Pediatric Surgery, Department of Surgery (Dr Weitzman), Childrens Hospital of Los Angeles; and the University of Southern California School of Medicine, Los Angeles.

Am J Dis Child. 1981;135(2):112-117. doi:10.1001/archpedi.1981.02130260004003

• The results of medical and surgical therapy were determined in 107 hyperthyroid children. After surgery, 85% of patients were rendered free of hyperthyroidism; however, 62% became hypothyroid. After medical treatment, 30% of patients were euthyroid and 2% became hypothyroid. The relapse rate, however, was higher after medical (22%) than after surgical (9%) therapy. Serious drug-related complications (arthritis-, hepatitis-, and collagen disease-like syndromes) occurred in 14% of patients. Complications occurred in 9% of surgically treated patients, but recurrent laryngeal nerve injury or permanent hypoparathyroidism did not occur. In medically treated patients, both a goiter size less than three times normal prior to treatment and a reduction in goiter size to less than two times normal at the completion of therapy correlated with a successful outcome.

(Am J Dis Child 1981;135:112-117)

Add or change institution