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February 1981

Furazolidone and Quinacrine: Comparative Study of Therapy for Giardiasis in Children

Author Affiliations

From the Section of Infectious Diseases, Department of Pediatrics, University of Texas Southeastern Medical School, Dallas. Dr Craft is now at Tulane University School of Medicine, New Orleans.

Am J Dis Child. 1981;135(2):164-166. doi:10.1001/archpedi.1981.02130260056016

• Furazolidone and quinacrine hydrochloride were compared for efficacy, toxicity, and ease of administration in 45 young children with giardiasis. With the initial course of therapy, the cure rate was 89% (17/19) with furazolidone and with quinacrine it was 64% (9/14) in children less than 5 years and 92% (11/12) in older children. Cure rates for all courses of therapy were 92% (24/26) with furazolidone and 53% (9/17) and 92% (12/13) in the younger and older children, respectively, treated with quinacrine. Quinacrine failure was usually due to severe vomiting. When re-treated with furazolidone, patients were cured. The disadvantages of furazolidone are the large volume of doses and the expense. In this study, furazolidone was more effective and better tolerated than quinacrine for the treatment of giardiasis.

(Am J Dis Child 1981;135:164-166)