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April 1981

Etiology and Morphogenesis of Congenital Heart Disease

Author Affiliations

Children's Hospital Elland and Bethesda avenues Cincinnati, OH 45229

Am J Dis Child. 1981;135(4):389-390. doi:10.1001/archpedi.1981.02130280077037

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This volume is a by-product of a symposium on the etiology and morphogenesis of congenital heart disease that took place in September 1978 in Tokyo. As stated in the preface, the book deals with "genetics, chromosomal abnormalities, normal cardiac embryology, experimental teratology and clinical-pathological-embryologic correlations of developmental interest." Basic research and its clinical applications also are considered, as well as the "latest" recurrence risk figures for the various types of congenital heart disease to be used in genetic counseling. One can gather from these prefatory remarks that this book has no conceptual unity, but represents a collection of 22 independent chapters written by 48 contributors from America, Europe, and Asia. Consequently, the articles are of differing quality and of different value to various readers. For the experimentalist, there are chapters on avian, rodent, and canine genetics and teratology of congenital heart disease; and there are chapters on cellular mechanisms during

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