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July 1981

Evaluation of the Cardiac Effects of Doxorubicin by Serial Echocardiography

Author Affiliations

Yvonne Carnahan
From the Departments of Pediatrics (Drs Hutter and Sahn, and Ms Carnahan) and Radiology (Dr Woolfenden), University of Arizona Health Sciences Center, Tucson.

Am J Dis Child. 1981;135(7):653-657. doi:10.1001/archpedi.1981.02130310057019

• Serial echocardiographic studies were performed on 48 children who received chemotherapy with doxorubicin hydrochloride (Adriamycin). For the group as a whole, no correlation could be made between the cumulative dose of doxorubicin administered and left ventricular systolic function as measured by the fractional shortening of the left ventricle (Δs). Two asymptomatic patients, however, demonstrated depressed Δs and abnormal results from radionuclide studies at cumulative doxorubicin doses of less than 430 mg/sq m. Differentiation of the echo-derived curve of left ventricular minor axis dimension indicated that these two patients had abnormalities in both diastolic and systolic function. Good correlation was demonstrated between echocardiographic and radionuclide studies in eight patients, including the two with depressed function. Inherent variability limits the sensitivity of echocardiographic functional studies, but serial studies are helpful in the evaluation of cardiac function in children who receive doxorubicin.

(Am J Dis Child 1981;135:653-657)