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August 1981

Neutrophil Functions and Mitogenic Response to Ascaris Antigen in Visceral Larva Migrans

Am J Dis Child. 1981;135(8):770. doi:10.1001/archpedi.1981.02130320078030

Sir.—We were very interested in the report by Caldwell et al (Journal 1980;134:845-847) on neutrophil functions and mitogenic response to parasitic antigens in visceral larva migrans (VLM).

We studied neutrophil functions and lymphocyte mitogenic response to Ascaris suum extracts in a 3-year-old patient with VLM.1

Neutrophil chemotaxis using Escherichia coli-lipolysaccharide—activated human normal serum as chemoattractant was persistently defective and the IgE level always high (> 1,000 IU/mL); transient defects of bactericidal activity and metabolic activation, present at the onset, disappeared after therapy.

As suggested by Hill and Quie,2 the high IgE level may also have been responsible in our patient for the chemotaxis defect.

Ascaris suum extracts have been used as an effective carrier and adjuvant for IgE production against various antigens in animals.3

The mitogenic response of peripheral blood lymphocytes (PBL) of our patient to various mitogens (phytohemagglutinin, concanavalin A, and pokeweed mitogen) was