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September 1981

Elevated GGTP/SGOT Ratio: An Early Indicator of Infantile Obstructive Cholangiopathy

Author Affiliations

From the Departments of Pathology (Drs Platt and Potter and Mr Jaberg) and Surgery (Dr Boeckman), Children's Hospital Medical Center of Akron (Ohio).

Am J Dis Child. 1981;135(9):834-836. doi:10.1001/archpedi.1981.02130330044014

• Early surgical intervention in cases of extrahepatic biliary atresia improves prognosis. The ratio of serum γ-glutamyl transpeptidase to SGOT is elevated in infants with infantile obstructive cholangiopathy. This appears to be a sensitive method for distinguishing infants with extrahepatic biliary atresia from those with neonatal hepatitis. This distinction was evident as early as 5 to 14 days of age and was clearly manifest in ten of 12 infants with biliary atresia. The ratio was also elevated in patients with α1-antitrypsin deficiency who had bile duct proliferation. We do not claim that the ratio can clearly distinguish extrahepatic biliary atresia from neonatal hepatitis, but we do suggest that an elevation raises a strong presumption of biliary obstruction and invites early consideration of laparotomy and examination of the biliary tree.

(Am J Dis Child 1981;135:834-836)

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