This article is only available in the PDF format. Download the PDF to view the article, as well as its associated figures and tables.
In Reply.—Dr Schwartz's comments reaffirm our cautious interpretation of the significance of finding C difficile toxin in association with use of antibiotics and the development of colitis in this neonate. Indeed, we recently found that as many as 10% of all normal babies and 50% of all severely ill infants have C difficile toxin in their stools in the absence of colonic disease. However, we, as well as other investigators, have not detected fecal toxin in infants with necrotizing enterocolitis. The infant we described did not have pneumatosis intestinalis, but did have stool toxin, making the diagnosis of C difficile toxin-associated colitis highly plausible.
DONTA ST, MYERS MG. Antibiotic-Associated Colitis-Reply. Am J Dis Child. 1981;135(9):864. doi:10.1001/archpedi.1981.02130330074028
Customize your JAMA Network experience by selecting one or more topics from the list below.
Create a personal account or sign in to: