• Concentrations of eight complement components were determined on sera from 419 healthy children (198 boys and 221 girls) aged from 1 to 19 years. A significant correlation between concentration and age for all complement components (C1q, C1s, C4, C3, C5, factor B, properdin, and C[unk] inhibitor) was observed for girls; in the male population, a significant correlation was present only for C1q, C4, C3, C5, and properdin. The presence of a significant relationship to age suggests that this variable must be considered in establishing normal values of serum complement for children.
(Am J Dis Child 1981;135:918-920)
Roach B, Kim Y, Jerome E, Michael AF. Influence of Age and Sex on Serum Complement Components in Children. Am J Dis Child. 1981;135(10):918–920. doi:10.1001/archpedi.1981.02130340030011
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