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January 1982

Cefaclor Therapy Twice Daily for Acute Otitis Media: Controlled Comparative Study of Twice-Daily vs Thrice-Daily Dose Schedule

Author Affiliations

From the Division of Infectious Diseases, Department of Pediatrics, University of Oklahoma Health Sciences Center, and Oklahoma Children's Memorial Hospital, Oklahoma City.

Am J Dis Child. 1982;136(1):33-35. doi:10.1001/archpedi.1982.03970370035008

• Cefaclor, a new orally administered cephalosporin, was used in a dose of 40 mg/kg/day for the treatment of acute otitis media in 60 children. The effectiveness and safety of this dose in a twice-daily vs thrice-daily regimen were compared. There were no differences in the clinical response between the two treatment groups. The drug was well tolerated by all patients, and no major clinical or laboratory toxic effects were observed. The twice-daily regimen did not improve compliance.

(Am J Dis Child 1982;136:33-35)