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January 1982

Penicillin-Resistant Streptococcus constellatus as a Cause of Endocarditis

Author Affiliations

From the Departments of Pediatrics (Drs Levin, Mondry, Levy, and Grossman) and Laboratory Medicine (Drs Pulliam and Hadley), University of California, San Francisco, and San Francisco General Hospital.

Am J Dis Child. 1982;136(1):42-45. doi:10.1001/archpedi.1982.03970370044011

• Endocarditis in a 2-year-old child was caused by a penicillin-resistant Streptococcus constellatus. Viridans streptococci in general and those associated with endocarditis in particular are usually believed to be penicillin sensitive. Although the patient did not receive prophylactic antibiotics, the child had recently been treated with an oral penicillin. Penicillin-resistant viridans streptococci are usually sensitive to the synergistic effects of penicillin and an aminoglycoside, but this organism was not. Clindamycin was ultimately shown to demonstrate admirable bactericidal activity against this patient's S constellatus.

(Am J Dis Child 1982;136:42-45)