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February 1982

Second Malignancy in Acute Lymphocytic Leukemia-Reply

Author Affiliations

Section of Pediatric Hematology-Oncology Department of Pediatrics Fitzsimons Army Medical Center Aurora, CO 80045
Section of Pediatric Hematology-Oncology Department of Pediatrics Walter Reed Army Medical Center Washington, DC 20012

Am J Dis Child. 1982;136(2):176. doi:10.1001/archpedi.1982.03970380087025

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In Reply.—The remarks of Dr Inoue and colleagues are important and suggestive of underlying host alteration in some cases of second malignancy. These authors and their co-workers have contributed greatly to our knowledge of the cytogenetic changes in malignant disease. We have had a preoccupation with classifying leukemia. One of us (P.J.T.) has observed a recent case consistent with the remarks of Dr Inoue and colleagues on juvenile-type CML. A 2-year-old boy had a typical Ph1-negative, juvenile CML and elevated fetal hemoglobin values. A brief remission was induced; the next relapse was erythroleukemia. A second remission was achieved. The second relapse was histochemically confirmed acute monocytic leukemia. Dr Inoue and associates would probably agree with us that this "three-in-one hit" represents three phases of one leukemia.

Transmissible, oncogenic nucleoprotein, such as the bacterial plasmid factors in ampicillin-resistant Escherichia and Salmonella, may be operative in leukemias that cross different

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