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April 1982

Fetal and Maternal Virilization Associated With Pregnancy: A Case Report and Review of the Literature

Author Affiliations

From the Division of Endocrinology, Edward Mallinckrodt Department of Pediatrics (Drs Cohen and Weldon), and the Department of Medicine (Dr Daughaday), Washington University School of Medicine, St Louis.

Am J Dis Child. 1982;136(4):353-356. doi:10.1001/archpedi.1982.03970400071018

• A masculinized female infant was born to a mother who had virilizing signs dating from the fourth month of pregnancy. Serum 17 α-hydroxyprogesterone, dehydroepiandrosterone, and testosterone levels were all normal in the infant. Maternal testosterone level was markedly elevated one week post partum. Dexamethasone phosphate suppression was normal. Human chorionic gonadotropin stimulation five weeks post partum revealed further elevation of high baseline free and total testosterone levels. Free and total testosterone levels 30 weeks post partum were normal, and all maternal virilizing signs had regressed with the exception of her deepened voice. The child has had no progression of masculinization. The mother is believed to have had a luteoma of pregnancy.

(Am J Dis Child 1982;136:353-356)